The current study revealed that ASIV significantly attenuated cardiac hypertrophy in CHF rat models of AAC and hypertrophic cardiomyocytes induced by Ang II via activating the Nrf2/HO-1 pathway (Figures 3(a)–3(e), 5(c)–5(g), and 7(h)–7(l)). This evidence concerns the gene HMOX1 and congestive heart failure.