In this regard, although the correlation of ALA with TNF-α, IL-6, IL-1β, SOD, GPx, and 8-isoprostane was statistically significant, the effect of ALA was not sufficient to show statistically significant differences between the EG and PG in the blood concentration of these markers; therefore, our findings do not support the anti-inflammatory and antioxidant effect of ALA in older adults with type 2 diabetes mellitus with a dose of 600 mg/day of ALA for six months. Here, SOD1 is linked to type 2 diabetes mellitus.