HSPG2 and cancer: Additionally, five critical pathways [PLC-mediated cascade, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) signaling, AQP-mediated transport, epidermal growth factor receptor (EGFR) interaction with PLC-γ, and PLC-γ1 signaling] and several GO processes were identified as potential mechanisms underlying the effects of miR-146a-5p in cancers.