Bell et al. and Mancini et al. further showed that GA-binding proteins (GABPA and GABPB1), the members of the ETS family transcription factors, were specifically recruited to the mutant rather than wt TERT promoter in cancer cells, thereby activating TERT transcription and telomerase (Fig. 2) [55, 56]. The gene discussed is GABPB1; the disease is cancer.