TERT and cancer: Nault et al. [81] showed that AAV2 DNA was integrated into the host genome in 11 of 193 HCC tumors and all the breakpoints affected cancer-related genes including TERT. The 208 bp AAV2 DNA fragment, cloned from the patient tumor and when inserted into the TERT promoter reporter construct, significantly increased luciferase activity, suggesting a functional significance of the inserted AAV2 sequence in telomerase activation [81].