First, GABPA depletion leads to significant downregulation of TERT expression in TC-derived cells independently of TERT promoter mutations; Second, GABPA expression is negatively correlated with TERT expression in primary tumors from TC patients; Third, GABPA depletion robustly increases thyroid cancer cell invasion despite a diminished TERT expression. Here, TERT is linked to thyroid gland carcinoma.