TERT and cancer: We learnt much from the cloning of the TERT gene and its promoter, and identification of its key transcription factors (both positive and negative), however, the findings made in the past 6 years have significantly contributed to our in-depth understanding of telomerase biology in cancer, and the genomic aberrations have started to take center stage: the hotspot mutation at 5’ regulatory promoter region and rearrangements at the TERT locus are emerging as new players in activating TERT transcription.