Previously, network analysis of SMLM Cav1 data sets in PC3 prostate cancer cells27, that express Cav1 but no CAVIN1 and therefore no caveolae1, identified two classes of Cav1 scaffolds corresponding to small Cav1 homo-oligomers (S1 scaffolds) that correspond to 8S Cav1 oligomers14,28, as well as larger hemispherical S2 scaffolds. This evidence concerns the gene CAVIN1 and Familial prostate cancer.