LEP and Obesity: In this study, we also confirmed study-wide significant association with risk of obesity and overweight at 10-year follow-up for either GPSall (OR [95%CI]: 1.138 [1.066, 1.214]; P = 9.3 × 10−5) or GPSleptin (1.183 [1.079, 1.296]; P = 3.2 × 10−4) (Supplementary Table 1); however, no association for GPS after excluding the six leptin-related SNPs was observed, thus further polygene analyses were restricted to GPSleptin.