All patients underwent panel testing of at least 14 CRC predisposition genes, including APC and MUTYH. However, only POLD1 and POLE were tested on a subset of the adenoma cohort, and the remaining adenomatous polyposis predisposition genes (NTHL1, AXIN2 and MSH3) were not tested20. This evidence concerns the gene MSH3 and colorectal carcinoma.