Other works analyzing AAP cohorts, such as Grover30 who analyzed MUTYH and APC in 4223 patients with 10 to 100 adenomas, or Stanich20 who also analyze POLD1 and POLE and other CRC genes in 2979 patients with 10 to 100 adenomas, showed similar clinical results. The gene discussed is POLD1; the disease is colorectal carcinoma.