MUTYH and polyposis: In addition, the screening of the whole coding sequence of MUTYH, allowed the detection of two MUTYH non-recurrent mutations, c.739C > G p.(Arg247Gly) and c.1510_1517delinsCCAACAGCCA p.Thr504Profs*68, both in co-occurrence with the recurrent mutation c.1187G > A; p.(Gly396Asp), being able to explain the polyposis susceptibility in two more subjects (Fig. 1a).