However, all adenomas and the adenocarcinoma tested from the carrier showed a decrease in the expression of POLE wild type allele (FD average = 0.46 ± 0.20, ρ < 0.001), whereas NTHL1 wild type allele showed significant over-expression in one adenoma and one adenocarcinoma from the proband when compared to its healthy tissue (ρ = 0.0156 and ρ < 0.001, respectively) (Fig. 2c,d). Here, POLE is linked to adenocarcinoma.