Moreover, there was a substantial but non-significant increase in tumour growth in mice receiving LONG R3 IGF-I (911 ± 360 mg, p = 0.08) or LONG R3 IGF-I with SB431542 (829 ± 371 mg, p = 0.44) compared to untreated, C26 TB mice (635 ± 218 mg) (Fig. 4E). This evidence concerns the gene IGF1 and neoplasm.