However, in vivo supplementation of similar growth factors, i.e. growth hormone-releasing hormone (GHRH) and a recombinant human IGF-I/insulin-like growth factor binding protein-3 complex (rhIGF-I/IGFBP-3) as a potential treatment for cancer cachexia had no effect on tumour growth47,48. Here, IGFBP3 is linked to cancer.