For example, we find pleiotropic association between expression levels of the HSD17B10 gene with obesity-related traits (Fat% and BMI) and EA.  Notably, HSD17B10 encodes a mitochondrial enzyme involved in oxidation of neuroactive steroids, fatty acids as well as sex hormones and its deficiency is implicated in neurodegenerative disorders32. This evidence concerns the gene HSD17B10 and obesity due to melanocortin 4 receptor deficiency.