For example, we find pleiotropic association between expression levels of the HSD17B10 gene with obesity-related traits (Fat% and BMI) and EA.  Notably, HSD17B10 encodes a mitochondrial enzyme involved in oxidation of neuroactive steroids, fatty acids as well as sex hormones and its deficiency is implicated in neurodegenerative disorders32. The gene discussed is HSD17B10; the disease is Obesity.