CTNNB1 and cancer: Although we observed that GSK-J4 treatment activated pathways involved in transcriptional mis-regulation in cancer, we demonstrated that several epithelial mesenchymal transition (EMT) genes, that are activated in many cancers36, such as SNAIL, TWIST and ZEB1 and several genes involved in beta-catenin pathways, chromatin remodeling and angiogenesis, that are specifically upregulated during HCC tumorigenesis37,38, didn’t change their expression level after GSK-J4 treatment, as shown in Supplementary Table S2.