GRN and liver dysplastic nodule: Importantly, we explored a novel role of PGRN in maintaining mitochondrial homeostasis via PGRN-Sirt1-PGC-1α/FoxO1 signaling-mediated mitochondrial biogenesis and mitophagy in podocytes, suggesting that targeting mitochondrial function and cellular bioenergetics upstream of cellular damage by PGRN may provide unexpected opportunities for the treatment of DN.