NPPA and persistent truncus arteriosus: The expression of other classic cardiac hypertrophic genes, such as those encoding ANP, brain natriuretic peptide (BNP), α-sarcomeric actin, interleukin 6, and regulator of calcineurin (CaN) 1.4 (Rcan1.4), and fibrotic genes, such as those for the transforming growth factor beta 1 (TGF-β1), collagen-1 (Col-1), and collagen-3 (Col-3) were also upregulated in the cardiac tissue of WT mice subjected to TAC compared to the sham group, while CTRP3 deficiency exaggerated this effect (Fig. 1j).