C1QTNF3 and cardiac hypertrophy: When Ctrp3-KO mice were treated with SB203580 after TAC, the cardiac hypertrophy (Fig. 5c, d) and fibrosis (Fig. 5c, e) aggravated by CTRP3 deficiency were significantly improved, as well as the damage of cardiac function (Fig. 5a) and increased HW/BW (Fig. 5b).