These observations together with our report of an MCL-1 inhibitor (A-1210477), inducing extensive, DRP-1-mediated mitochondrial fission in several cell lines, including H1299, a non-small cell lung carcinoma cell line18, led us to question whether ER membrane reorganisation would alter A-1210477-mediated mitochondrial fission. Here, MCL1 is linked to small cell lung carcinoma.