Interestingly, a small LGR5+/EpCAM− subset was detected in all linessph, probably representing the CD26+/CD44+/CD66c+ but EpCAM(CD326)− and CD133− CTC population that was an independent prognostic factor for CRC recurrence (Lieto et al., 2015). This evidence concerns the gene CD44 and colorectal carcinoma.