From present knowledge, CRC MetSCs can be found among the cell population with a high expression of Wnt targets LGR5+ and EphB2+ (de Sousa e Melo et al., 2017; Jung et al., 2011; Kemper et al., 2012) co-expressing EpCAM, CD133, CXCR4 and CD26 markers. Here, DPP4 is linked to colorectal carcinoma.