Therefore, as LGR5 and E-cadherin expression correlate in sphere cells (Fig. 3A) – as well as LGR5 with EpCAM (Fig. 2) and with CD26 (Fig. 3B), and also E-cadherin with CD26 (Fig. S6) but not with CD133 (Fig. 3C) – it can be deduced that, in sphere derived cells from lines of advanced tumor stage, the E-cadherin+/LGR5+/EpCAMhigh cells are also CD26high. The gene discussed is LGR5; the disease is neoplasm.