PCBP2 and cardiac hypertrophy: One module in the heart is controlled by Pumilio RNA binding family member 2 (PUM2), which is known to drive glial scar formation, a fibrotic and TGFβ1-dependent process in the brain.38 Others are regulated by QKI, important in heart development,39 or PCBP2, which is known to inhibit cardiac hypertrophy driven by the fibrogenic stimulus angiotensin 2.40 Interestingly, we detected a large overlap between targets of regulators, suggesting that the concerted action of several RBPs determines the translational efficiency of bound transcripts.