HK-2 (Hexokinase-2) was also shown to be a direct target of miR-9-5p, which in turn contributes to GDM progression by regulating gene expression related to glycolytic pathways and the mitochondrial complex, as well leading to a decrease in the expression of GLUT1 (glucose transporter 1), PFK (phosphofructokinase) and LDH (lactate dehydrogenase), at both mRNA and protein levels [36]. The gene discussed is SLC2A1; the disease is gestational diabetes.