For example, T47D breast cancer cells which are TRAIL resistant due to autocrine CD40L-CD40 signaling can be efficiently killed by a fusion protein of soluble TRAIL with the extracellular domain of CD40 which links the anchoring of soluble TRAIL trimers with the blockade of the protective autocrine CD40L-CD40 survival loop [131]. Here, TNFSF10 is linked to breast carcinoma.