HSD3B1 and ovarian carcinoma: In addition, they analyzed acrylamide-gene interactions that were associated with the ovarian cancer risk [135], and concluded that there were statistically significant interactions between several single nucleotide polymorphisms (SNPs) in the HSD3B1/B2 gene cluster and the acrylamide intake that were associated with the ovarian cancer risk, suggesting that acrylamide may cause the development of ovarian cancer through its effects on sex hormones [135].