In the case of NPC, UBR5-ZNF423 fusion gene which is a hybrid gene formed from exon 1 of UBR5 and exons 7–9 of ZNF423 (EBFs binding domain), is an oncogene that drives proliferation and colony forming ability via suppression EBFs activities [10]. This evidence concerns the gene ZNF423 and nasopharyngeal carcinoma.