Kim et al. generated a 2’-fluoro-uridine modified RNA aptamer (P12FR2) that binds specifically to human pancreatic adenocarcinoma upregulated factor (PAUF), and showed the oncosuppressive role of P12FR2 both in vitro and in vivo, suggesting that P12FR2 is a potential therapeutic target of human pancreatic cancer [94]. This evidence concerns the gene ZG16B and familial pancreatic carcinoma.