EGFR and familial pancreatic carcinoma: Based on the evidence that most pancreatic cancers overexpress epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase [98], the authors generated a nuclease-resistant RNA aptamer, and found that the aptamer was internalized by EGFR on human pancreatic cancer cells by efficiently delivering gemcitabine-containing polymers into EGFR-expressing cells, resulting in the in vitro inhibition of the proliferation of pancreatic cancer cells [99].