ANXA1 and familial pancreatic carcinoma: Subsequently, Belvedere et al. revealed the role of miR-196a (a well-known oncogenic factor) as a function of Annexin A1 (a Ca2+-binding protein that is involved in pancreatic cancer development) in MIA PaCa-2 pancreatic cancer cells, obtained by an in vitro CRISPR/Cas9 genome editing system [118].