The NLRP3 inflammasome is critical for host immune defenses against bacterial, fungal, and viral infections [20,21,22,23]; however, it has been linked to the pathogenesis of several inflammatory disorders when dysregulated, including cryopyrin-associated periodic syndromes (CAPS), Alzheimer’s disease, diabetes, gout, autoinflammatory diseases, and atherosclerosis [24,25]. Here, NLRP3 is linked to Alzheimer disease.