Medina et al. demonstrated that TFEB overexpression induced lysosomal exocytosis and promoted cellular clearance in cell models of various LSDs, including multiple sulfatase deficiency (MSD) and mucopolysaccharidoses type IIIA (MPS-IIIA), both characterized by severe neurodegeneration due to glycosaminoglycan (GAG) accumulation, as well as Batten disease, a type of neuronal ceroid lipofuscinosis, and Pompe disease, a type of glycogenosis [121]. The gene discussed is TFEB; the disease is Multiple sulfatase deficiency.