CHMP2B and amyotrophic lateral sclerosis: The degradative function of ubiquitin tagged proteins via formation of exosomes is fundamental, as demonstrated by the evidence that mutations in CHMP2B, a key component of ESCRT-III, were identified in frontotemporal dementia (FTD) linked to chromosome-3 (FTD-3) and in amyotrophic lateral sclerosis (ALS), pathologies characterized by the accumulation of ubiquinated inclusion in neurons [36].