GLP1R and type 2 diabetes mellitus: Additionally, independent predictors of change in FMD were age, duration of type 2 diabetes, treatment with basal insulin analogs, and treatment with DDP-4 inhibitors and GLP-1 receptor agonists (incretin-based agents), but not the change in HbA1c (p > 0.05) after 1 year of treatment (Table 3).