Also, FGE was shown to alleviate pulmonary hypertension by decreasing the expression of vascular endothelial cell adhesion molecule-1 and matrix metalloproteinase-9 (MMP-9) and increasing the expression of PKG and endothelial nitric oxide synthase (eNOS) in monocrotaline-induced pulmonary hypertension rats [77]. This evidence concerns the gene PRKG1 and pulmonary hypertension.