In PCa, secreted protein acidic and cysteine rich, osteonectin (SPARC), cwcv, and kazal-like domains’ proteoglycan 1 (SPOCK1) increases with the progression of human PCa through epithelial-to-mesenchymal transition signaling, which contributes to proliferative and metastatic activities in vitro and in vivo [5]. The gene discussed is SPOCK1; the disease is posterior cortical atrophy.