IFNG and colitis: In addition, DHA inhibited the expression of RORγt (Retinoid-related orphan receptorγt) (Th17) and enhanced the expression of Foxp3 (Treg) in the TNBS colitis model, and 4 mg/kg DHA per day increased IL-10 expression levels significantly; however, DHA had no obvious effect on the expression levels of T-bet (Th1) and IFNγ (Interferronγ) (Figure S3B).