Sanchez-Martinez et al. reported that the observed SCD1-dependent increase in colon cancer cell migration and invasiveness resulted from the synergistic action of SCD1 with the long-chain acyl-CoA synthetases acyl-CoA synthetase long-chain family member 1 (ACSL1) and ACSL4 [120]. Here, ACSL1 is linked to malignant colon neoplasm.