The treatment of renal, thyroid, liver, and lung cancer cells with the SCD1 inhibitor, A939572, mostly under restricted nutrient conditions, upregulates a set of gene markers of UPR and ER stress, including CHOP, binding immunoglobulin protein (BiP), Tribbles pseudokinase 3 (TRIB3), ATF6, DNA damage-inducible transcript 3/4 protein (DDIT3/4), homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), and growth arrest and DNA damage-inducible α (GADD45α) [27,60,71,73]. This evidence concerns the gene HERPUD1 and lung cancer.