Another mechanism implicating SCD1 and the Wnt/β-catenin pathway in CSC-related tumor development has been proposed by Lai et al. The authors highlighted that Wnt/β-catenin-driven expression of SCD1, and in turn, MUFA synthesis, amplifies Wnt signaling via stabilization of β-catenin and low-density lipoprotein receptor-related proteins 5 and 6 (Lrp5 and 6) mRNA in rodent hepatic stellate cells (HSCs) and tumor-initiating stem cell-like cells (TICs) from the liver [20]. Here, LRP5 is linked to neoplasm.