The result of western blotting showed that combining NOMAC and metformin treatments significantly inhibited the expression of phospho-mTOR (Ser 2448), phospho-4EBP1(Ser 65), and phospho-eIF4G (Ser 1108) compared to NOMAC or metformin treatments alone in the xenograft tumor tissues (p < 0.05 or p < 0.01, Figure 5F). Here, EIF4EBP1 is linked to neoplasm.