BRCA2 and Familial prostate cancer: Notably, overexpression of BRCA2 abolished any effects on prostate cancer cell proliferation in response to any compound tested and sensitized PC cells to apoptosis following treatment with 2-N-6-BP and 2,6-DTP (174% ± 12 and 187% ± 13, respectively, compared to untreated cells; p < 0.01).