ST3GAL5 and lysosomal storage disease: In ST3GAL5-CDG, the lack of ganglio-series gangliosides is probably accompanied by the accumulation of globosides, and mitochondrial defects are present, sometimes reported to misdirect the diagnosis [122], although brain mitochondria lack gangliosides [123]; we speculate that impaired mitophagy may occur in the disease as suggested for lysosomal storage diseases [124].