BCL2 and malignant colon neoplasm: Moreover, magnetic particles could also be applied in gene therapy, as Bag-1, a positive regulator of the anti-apoptotic Bcl-2 gene, which is generally over-expressed in colon cancer, was immobilized onto magnetic gold nanoparticles along with siRNA for cell transfection, which could be potentially used in cancer treatment through siRNA silencing method [102].