NFE2L2 and neurodegenerative disease: Curcumin activates many antioxidant systems, such as nuclear factor erythroid 2-related factor 2 (Nrf2), hemeoxygenase1 (HMOX-1), heat shock proteins 70 (Hsp70s), and thioredoxin, causing neuroprotective effects and representing an innovative approach to therapeutic intervention in neurodegenerative diseases [42].