CXCL8 and familial dilated cardiomyopathy: Unique identifier: NCT00692237) at the initial stage of DCM, blood level of CXCL10 and CXCL8 was significantly reduced after three month treatment with the phosphodiesterase inhibitor 5 (PDE5i) sildenafil (100 mg/day), vs. placebo; at the same time, whereas drug intake modified metabolic parameters (hemoglobin A1c, post-prandial glycemia and lipidemic profile [133]), it failed to change cardiac standard markers (ejection fraction, mass and volume index or blood pressure).