It is known that Complement is the driving force in the pathophysiology of I/R injury-induced AKI [34, 35] and C5a, the most powerful anaphylatoxin, is able to bind two kind of receptors (C5aR1 and C5aR2), both expressed on renal tubular epithelial cells [36, 37]. Here, C5AR1 is linked to acute kidney injury.