Such data have led to the ‘interneuron hypothesis’ of DS, which posits that PV and SST-IN dysfunction is the predominant driver of both epilepsy and autism (Catterall, 2018; Catterall et al., 2010; Han et al., 2012; Ogiwara et al., 2007; Rubinstein et al., 2015; Yu et al., 2006). Here, SST is linked to Dravet syndrome.