CBL and cancer: We hypothesized that the c-Cbl recognition site in LynA must lie within the unique-region insert (residues 23–43), absent in LynB (Yi et al., 1991; Stanley et al., 1991), which contains a tyrosine residue reported to be phosphorylated in cancer cells (Y32; Huang et al., 2013; Tornillo et al., 2018), a predicted threonine phosphorylation site (T27; NetPhos 3.1, Blom et al., 2004) and a predicted lysine ubiquitination site (K40; UbPred, Radivojac et al., 2010) (Figure 3D).