We now present provocative preliminary data from patients with Parkinson's disease where rather than increased MsrB2 and increased mitophagy as in DM, there is now reduced MsrB2 and reduced mitophagy, supporting our premise on the potential importance of MsrB2 in mitophagy and possibly importance in the process of aging and neurodegeneration. Here, MSRB2 is linked to Parkinson disease.