We also show that RIG-I and MDA-5 are mainly upregulated in D5-hNPCs, as compared to undifferentiated cells, whereas the analysis of IFN gene expression profile indicated that IFN-β and IFN-λ are the two main IFN genes that are induced during ZIKV infection of hNPCs. The gene discussed is IFIH1; the disease is Zika virus infectious disease.