A study by our group suggested that STC1 was a novel non‐canonical NOTCH ligand and acted as a crucial regulator of stemness in GBM.48, 49 KCNK3‐regulated apoptosis and proliferation in a subset of NSCLC.50 MB was found to be expressed in various tumours and could be associated with metastasis.51 Among these genes, TGFB1, PDGFB, CXCR4, HMOX1, STC1, PLOD1 and MB have been reported as downstream targets of HIF. This evidence concerns the gene CXCR4 and glioblastoma.