Cytokines have been well documented to participate in GBM initiation and progression,19 but the reports on the TLR signal pathway are very limited and the functions of TLR in GBM remain unclear.20, 21 Further analysis on TLR6 signal pathway revealed a panel of up‐regulated genes, including CCL3, IL1B, IL6, LY96, PIK3CD, SPP1, TICAM1, TICAM2, TLR6 and TOLLIP, which were further verified by qPCR (Figure 1D and Figure S1). This evidence concerns the gene TOLLIP and glioblastoma.