The protective role of 4‐OHT against cardiovascular diseases appears to be indirectly due to lipid reprogramming mediated by drug56 and to the cholesterol pathway association to altered gene expression patterns that can partially explain the Tam resistance of cells.57 Thus the downregulation of most proteins showed in Figure 4A could indicate a positive impact of Tam on cardiomyopathy pathways in MCF‐7 cell. Here, STIM1 is linked to cardiomyopathy.