Many more proteins showed appreciable spatial changes in compartmental abundance than in total protein abundance.14 We suggested14, 15 that major alterations in the spatiotemporal subcellular distribution of proteins are the dominant response of MCF‐7 cells to estradiol exposure, that a major role of the estrogen receptor and possibly other nuclear hormone receptors may be the “polling” of and response to spatially distributed functional networks, and that strong perturbation of subcellular spatial regulation may be a crucial feature of breast cancer. Here, ESR1 is linked to breast cancer.