Indeed, invasion and metastasis have been attributed to GNA proteins in many cancer types.62 Some findings reported that GNA13 is highly upregulated in the aggressive form of breast cancer cells31 and restoration of GNA13 activity has been shown to enhance the progression and invasion characteristics of prostate and gastric cancer cells.63 We found that under 4‐OHT stimulation GNA13 were highly expressed in the cytoplasmic and nuclear fraction and in the total lysate while GNAQ were upregulated in the total and nuclear fraction without any change in cytoplasmic compartment (Figure 4B). This evidence concerns the gene GNA13 and breast cancer.