NFKB1 and breast cancer: Constitutive activation of the NF‐κB transcription factor is associated with disease progression, distant reoccurrence and reduced survival outcome in breast cancer.3 Basal‐like and triple negative breast cancers demonstrate elevated nuclear NF‐κB expression and activity compared to luminal subtypes with or without HER2/ErbB2 amplification.4, 5, 6 It is widely accepted that the IKK‐IκB axis regulates canonical NF‐κB activation.