It was reported that the expression of COX‐2 was extremely low in normal liver,43 but was increased under pathological conditions such as acute liver failure,44 hepatic fibrosis and cirrhosis,45 and hepatocarcinogenesis.43 To date, the implication of COX‐2 in hepatic steatosis remains controversial. This evidence concerns the gene PTGS2 and Hepatic steatosis.