This result is contrary to an earlier study that reported no differences in RTE of CD4+CD25+ Tregs in NOD mice compared to diabetes-resistant strains [2] and could be due to the use of different markers to identify Tregs (i.e., CD25 vs Foxp3) in the two studies and/or the impact of the environment in different animal facilities as described below. The gene discussed is FOXP3; the disease is diabetes mellitus.