Another group of age DMR loci encodes proteins engaged in the functioning of the nervous system like STX2 (hypomethylated) being important for neurosecretion (nicotinic acetylcholine receptor signaling pathway P00044), NTN1 (hypermethylated) relevant for axon development (axon guidance mediated by Slit/Robo P00008), and FBXW11 (hypermethylated) showing neuroprotective effects in the form of slower progression of Parkinson's disease (Hedgehog signaling pathway P00025). The gene discussed is STX2; the disease is Parkinson disease.