Other age DMR-associated genes are important for the functioning of the immune system like IL13 (hypomethylated) involved in molecular pathways relevant for modulation of immune responses and immune cell development (interleukin signaling pathway P00036), RASGRP1 (hypomethylated) responsible for immune disturbance in aged individuals (heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha-mediated pathway P00027), and PTPN11 (hypomethylated) providing the immune support for cancer progression (interferon-gamma signaling pathway P00035) (Table S2). This evidence concerns the gene PTPN11 and cancer.