Further analysis of the gene frequency showed that the frequency of the −254G allele locus in SRNS children was significantly higher than that in SSNS children; the luciferase assays verified that this variant significantly upregulated TRPC6 promoter activity, suggesting that TRPC6 is not only involved in the development of kidney disease but may also be closely related to steroid resistance, and the −254C>G SNP may be significantly correlated with high TRPC6 expression [13]. Here, TRPC6 is linked to kidney disorder.