FGF2 and osteoarthritis: Through chromatin immunoprecipitation (ChIP) assays, Ji et al. confirmed that the NF-κB transcription complex p65 binds to the upstream promoter regions of miR-105 genes to silence transcription; p65 is recruited beforehand by the fibroblast growth factor 2 (FGF2), and miR-105 expression is restored by suppressing p65 in human osteoarthritis chondrocytes (56).