Taken together, the results from this study preliminarily demonstrated that the compounds isolated from Rubus species (C1 and C2) induce apoptosis in human breast cancer cells by causing accumulation of intracellular ROS, by activation of mitochondrial signaling pathway by showing higher expression of cleaved PARP, caspase 9, cytochrome c, and Bax apoptotic proteins. This evidence concerns the gene BAX and breast carcinoma.