CDK4 and breast cancer: There are many neoadjuvant trials to be considered, for instance, in luminal BC results derived from adding phosphoinositide 3-kinase inhibitor (PI3Ki) (LORELEI NEO-ORB) or cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) (PALLET, NEOMONARCH) to AI are very interesting; in HER2pos BC, the high pCR using Trastuzumab emtansine (T-DM1) with or without ET (ADAPT) is noteworthy, and in another ADAPT trial, it is interesting that with pertuzumab + trastuzumab, the pathological complete response rate (pCR) is 36%, but adding docetaxel achieves a pCR of 90%.