Guo et al. [36] showed that Coptis Chinensis could decrease the expression of NF-κB, increase the expression of PPAR-γ, and alleviate the pathological changes of kidney in STZ-induced diabetic rats. Huangkui capsules [37], a patent drug for DKD patients with damp heat syndrome, improved renal function, by decreasing 24 h proteinuria and serum creatinine, and inhibited the expression of hypersensitivity creative protein (Hs-CRP) and TNF-α, as shown by an 8-week clinical study involving 90 patients. The gene discussed is TNF; the disease is diabetic kidney disease.