Similar results were reported in Sanhuangtangshenkang granule [38] which could reduce serum fasting blood glucose (FBG), HbA1c, MALB, BUN, and CRP and alleviate microinflammatory stated by downregulating the expression of NF-κB, MCP-1, and CCR2 in DKD rats model. This evidence concerns the gene CCL2 and diabetic kidney disease.