SOAT1 and obesity due to melanocortin 4 receptor deficiency: Microinflammation involves the accumulation of inflammatory cells and overexpression of adhesion molecules, chemokines, and proinflammatory cytokines, along with the participation of pathways such as the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, which is common in obesity, DM, and DKD.