It has also been declared that ALS patients present signs of systemic inflammation, reflected in increased levels of CRP, tumor necrosis factor-alpha (TNF-α), interleukins (IL-6, IL-8), interferon-beta (IFN-β), and complement components such as C3 and C4 [34–36]. The gene discussed is IFNB1; the disease is amyotrophic lateral sclerosis.